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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Friedländer synthesis ： ウィキペディア英語版 Friedländer synthesis The Friedländer synthesis is a chemical reaction of 2-aminobenzaldehydes〔Organic Syntheses, Coll. Vol. 3, p.　56 (1955); Vol. 28, p.　11 (1948). ((Article ))〕 with ketones to form quinoline derivatives. It is named after German chemist Paul Friedländer (1857–1923). This reaction has been catalyzed by trifluoroacetic acid, toluenesulfonic acid, iodine, and Lewis acids. Several reviews have been published. ==Mechanism== Two viable reaction mechanisms exist for this reaction. In the first mechanism 2-amino substituted carbonyl compound 1 and carbonyl compound 2 react in a rate-limiting step to aldol adduct 3. This intermediate loses water in an elimination reaction to unsaturated carbonyl compound 4 and then loses water again in imine formation to quinoline 7. In the second mechanism the first step is Schiff base formation to 5 followed by Aldol reaction to 6 and elimination to 7. : The Pfitzinger reaction and the Niementowski quinoline synthesis are variations of the Friedländer reaction. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Friedländer synthesis」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.